The 9 Best Ergonomic Mice of 2021

Say goodbye to wrist pain

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Ergonomic mice are not only designed to keep you comfortable while you work, but they also allow you to customize input layouts and feature ultra-precise tracking sensors. While many mice still have a traditional horizontal design, some have a vertical body, which is meant to properly align your wrist and forearm for even more comfort. 

Most ergonomic mice are wireless and feature impressive battery lives, but some still allow for a hardwired connection via USB cable so you can use them while charging. A few mice also have ambidextrous designs that appeal to both left- and right-handed users. Whatever your needs, here are the best ergonomic mice available today.

Best Overall: Logitech MX Ergo Wireless Trackball Mouse

The Logitech MX Ergo is the king of ergonomic mice, and for good reason. It's designed to keep your hand, wrist, and forearm in neutral positions for more comfortable long-term use and to reduce muscle strain up to 20 percent for less fatigue. It also features an adjustable hinge so you can customize the trackball position to suit your grip style.

This wireless mouse connects to your PC or Mac computer via Bluetooth or USB, and you can connect it to two devices simultaneously and switch between them. Even more, the rechargeable battery gives you up to four months of use on a full charge, and just one minute of charging gives you all-day power.

Related: The Best Ergonomic Keyboards

Best Vertical Grip: Logitech MX Vertical Wireless Mouse

The Logitech MX Vertical may look a little funky, but it's specifically designed for maximum comfort. This wireless mouse places your hand in a neutral, "handshake" position that reduces wrist and arm strain. The optical sensor has a maximum sensitivity of 4,000 DPI (dots per inch), and you can set different levels and switch between them with a single button.

You can also connect this mouse to up to three PC or Mac computers at once via Bluetooth or USB. The rechargeable battery gives you up to four months of life on a full charge, and just one minute of charging gives you three hours of use. 

Most Quiet: Mojo Wireless Vertical Silent Mouse

Work all day without disturbing others with this Mojo mouse, which has six silent buttons. It even features a DPI switch, so you can choose from three different sensitivity levels: 800, 1,200, and 1,600 DPI. 

Its vertical design is meant to keep your hand, wrist, and forearm in a neutral position for more comfortable use and less muscle strain. It is also compatible with PC, Mac, and Linux-based computers and even Android and iOS mobile devices via Bluetooth. Note that this mouse is powered by two AAA batteries.

Best Wireless: Razer Viper Ultimate Hyperspeed Mouse

Though marketed towards gamers, Razer's Viper Ultimate Hyperspeed Mouse is just as useful for office workers. It features an ambidextrous design so that both left- and right-handed people can comfortably use it. Along with its incredibly lightweight body, the mouse's 20,000 DPI optical sensor means you get pixel-precise cursor placement with minimal movement.

It connects to your PC or Mac with a wireless dongle that works with Razer's proprietary Hyperspeed technology for a stable, low-latency connection. The integrated battery also gives you up to 70 hours of use on a full charge, though when you do need to recharge, use the included dock or a USB cable.

Related: The Best Wireless Mice

Runner-Up, Best Wireless: Razer Pro Click

Razer Pro Click

In a collaboration with Humanscale, the Razer Pro Click features added palm support to fit your hand naturally, as well as textured side grips to easily control the mouse. The 5G sensor has a maximum sensitivity of 16,000 DPI, while each button uses a mechanical switch for enhanced responsiveness and a lifespan of up to 50 million clicks. 

Connect this mouse to up to four devices simultaneously via Bluetooth, a wireless dongle, or a USB cable. The integrated battery also gives you up to 400 hours of use while connected via Bluetooth and up to 200 hours when connected with the wireless dongle.

Best for Apple Users: Apple Magic Mouse 2

Perfect for Apple users, the Magic Mouse 2 has a lightweight body and continuous-shell design that fits your palm for more comfort. The top of the mouse also supports Apple's Multi-Touch technology, allowing you to use touch-based inputs like swiping, zooming, and tapping to navigate web pages, documents, and programs.

It connects to your MacBook, iMac, or iPad via Bluetooth for instant pairing and a stable connection. The integrated battery also gives you up to 30 days of use on a full charge, and just two minutes of charging gives you up to nine hours of use.

Related: The Best Mouse Pads

Best Budget: Microsoft Bluetooth Mobile Mouse

Ideal for those on a budget, Microsoft's Bluetooth Mobile Mouse has a compact, ambidextrous design that is curved to fit either hand comfortably. It can be used with PC or Mac computers and Android mobile devices, connecting with Bluetooth for virtually lag-free inputs and instant pairing. 

The sensor also uses Microsoft's BlueTrack technology, so the mouse can be used on any surface except glass or mirrors—meaning you can use it without a mousepad. It's also powered by a single AA battery, which gives you an impressive 12 months of use before needing to be replaced.  

Best for Style: Microsoft Surface Arc Mouse

The Microsoft Surface Arc features a sleek, futuristic design that fits the natural curve of your hand and snaps flat to take with you in a bag. The single button works for right and left clicking as well as horizontal and vertical scrolling via touch inputs. Better yet, the optical sensor gives you precision tracking on almost any desk surface or mouse pad.

This mouse also pairs to your Windows-based computer via Bluetooth for instant pairing and low-latency input responses. It's powered by two AAA batteries that give you up to six months of use before needing to be replaced.

Best for Creative Professionals: Logitech MX Master 3 Mouse

If you're a creative professional, consider using the Logitech MX Master 3 for all of your art projects. The ergonomic design is meant to fit your palm's natural curves while keeping your wrist and forearm in neutral positions. It features conveniently placed buttons and a scroll wheel near the thumb rest for quick access to custom inputs. You can also customize inputs for each button or use the app-specific input layouts for programs like Photoshop, Final Cut Pro, and even Chrome.

This mouse connects to Mac-, PC-, and Linux-based computers via Bluetooth or a wireless dongle and can be used on up to three computers simultaneously. The integrated battery also gives you up to 70 days of use on a full charge, and just one minute of charging gives you up to three hours of use.  

Related: The Best Wireless Keyboards

Meet the Expert

Taylor Clemons has over three years of experience writing about games and consumer technology. She has written for Lifewire, Digital Trends, TechRadar, and her own publication, Steam Shovelers.